Sebastian Schneeweiss

Professor of medicine and epidemiology at Harvard Medical School and chief of the Division of Pharmacoepidemiology and Pharmaeconomics at the Bridger and Women's Hospital. PI of the FDA CDAP-funded Sentinel Innovation Center.

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Jun 16, 2025 • 52min

Real-World Evidence vs. Randomized Trials: Can We Emulate Accuracy?

Sebastian Schneeweiss, a Harvard Medical School professor specializing in medicine and epidemiology, shares insights on emulating randomized trials with real-world data. He discusses the motivation behind this approach, emphasizing its significance for regulatory-grade evidence. Topics include the challenges of data quality and adherence, use cases for real-world evidence in expanding treatment indications, and the innovative ‘Benchmark-Calibrate-Extrapolate’ strategy. This conversation is a must-listen for those in biostatistics, epidemiology, and healthcare innovation.

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