In this discussion, Dr. Scott Weingart, an ED Intensivist from New York with a rich background in Trauma and Critical Care, dives into the reliability of clinical trials. He highlights the challenges of replicating single-center randomized trials in larger, multi-center settings, pointing out significant discrepancies in outcomes. The conversation also touches on the importance of methodology in trial design and the real-world applicability of results, encouraging ongoing training and clinical judgment in emergency medicine.