Dr. Scott Canna discusses auto- and hyperinflammatory diseases, IL-18's role, and adapting therapies. The podcast highlights research on microbial metabolites, T cell tolerance, and microbes in immunotherapy. Dr. Canna delves into HLH, IL-18 in autoinflammatory diseases, and challenges in diagnosis and treatment. The episode also covers vaccine innovations during the pandemic and scientific achievements.

Dr. Ashish Kumar and Dr. Scott Canna discuss the challenges of diagnosing HLH, emphasizing the critical importance of a prompt diagnosis. They explore the complexities of HLH diagnosis, including the evolution of diagnostic criteria and the significance of genetic testing. The podcast highlights the limitations of current guidelines and the need for real-time resources to navigate diagnostic uncertainties.