Camille Casillas, a PGY2 Critical Care Pharmacy resident at MD Anderson, and Sarah Sindelar, also a PGY2 at Nebraska Medicine and an active voice on Twitter, dive into vital literature from July 2024. They discuss the TRACE III trial's impact on stroke protocols and innovative anticoagulation practices. The conversation shifts to the management of opioid-induced constipation with naloxegol versus methyl naltrexone. With a light-hearted mention of college football loyalty, they weave critical care insights into an engaging narrative.