Dr. Ruth Ley, a microbiome science expert, and Dr. Sara Clasen, a postdoctoral fellow, dive into the fascinating co-evolution of humans with their gut microbiomes. They discuss how gut microbes adapt to human biology and the silent recognition of flagellins by TLR5, crucial for immune regulation. The conversation also explores the interplay between intestinal IgA and circadian rhythms, as well as innovative CAR T-cell therapies using CRISPR. Together, they illuminate the mutual adaptations that impact health and the future of microbiome research.