In this engaging conversation, Sacha van Albada, a leading expert in theoretical neuroanatomy, shares insights on developing advanced multi-area cortex models for macaques and humans. He discusses the challenges of linking single-neuron activity to larger systems, the intricacies of simulating neural dynamics on supercomputers, and the importance of physiological data for accuracy. Sacha also highlights the significance of collaboration in improving models and explores concepts like predictive coding, making complex neuroscience more accessible for researchers.