Ruud Delwel

Researcher focused on leukemia biology who studies MECOM/EVI-1 function and contributed complementary experimental validation on MECOM as a repressor of myeloid differentiation.

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Dec 18, 2025 • 20min

Novel Differentiation Therapies for AML and Prognostic Value of PET in MM

Vijay Sankaran, a physician-scientist in hematology research, Ruud Delwel, a leukemia biology expert, and Françoise Kraeber-Bodere, a nuclear medicine physician, delve into groundbreaking studies on the MECOM gene's impact on acute myeloid leukemia therapies. They explore how MECOM repression might enhance CEBPA expression to promote differentiation in leukemias. Also discussed are the promising results from the CASSIOPET study showing that pre-maintenance PET negativity is a strong prognostic indicator for multiple myeloma outcomes.

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