Dr. Russ Poldrack, influential in fMRI and cognitive neuroscience, discusses paradigm shifts in fMRI best practices and challenges in brain imaging. Topics include the importance of replicability, the growth of OpenNURO for data sharing, predicting task information, AI advancements in cognitive function, the potential of GPT-3 for fMRI analysis, issues in research design, and analyzing individual subjects in fMRI. The future of fMRI and efforts to generate large datasets and bridge human-animal models using AI are also discussed.