Dr. Troum and Dr. Ruderman delve into the changing landscape of imaging for rheumatoid arthritis, revealing the reduced necessity for annual radiographs and spotlighting the roles of MRI and ultrasound. Dr. Cush discusses the complexities surrounding seropositivity, shedding light on how autoantibody levels impact diagnosis. Dr. Weinblatt emphasizes the pivotal role of methotrexate, discussing optimal dosing and monitoring practices. Lastly, Dr. Kavanaugh addresses the multifaceted challenges of managing difficult-to-treat RA, advocating for personalized treatment strategies.