Rocky Kolb, a distinguished astrophysicist and professor at the University of Chicago, discusses the power of mistakes in advancing science. He shares insights on balancing confidence with humility, emphasizing that acknowledging errors can lead to revolutionary discoveries. The conversation explores intriguing topics like the complexities of dark matter, the significance of mentorship, and the philosophical questions surrounding ethics in science. Kolb also dives into the challenges of interpreting data in cosmology and the evolving understanding of neutrinos.