Rita Rubin, Lead Senior Staff Writer for JAMA Medical News, and Kate Schweitzer, Associate Managing Editor, delve into pressing medical issues. They discuss the alarming rise of antimicrobial resistance, spotlighting the UN's focus on global disparities in antibiotic access. The conversation shifts to the XEC COVID variant, its potential to dominate the winter wave, and the importance of vaccination. Together, they highlight critical strategies needed to combat these public health challenges.

Rita Rubin, the lead senior staff writer for JAMA Medical News, dives into the latest findings on COVID-19 vaccines and their limitations in preventing transmission. She discusses the crucial need for mucosal immunity to effectively combat infections. The conversation also highlights the innovative 'Safer at Home' program, which allows patients to receive acute care virtually, reducing hospital stays and improving access to healthcare. A fascinating look at challenges in evaluating mucosal vaccines and the evolution of virtual care models adds depth to the discussion.

Sebastian Palmqvist, MD, PhD, and Wiesje van der Flier, PhD, are cochairs of the 2024 Alzheimer’s Association International Conference, while Rita Rubin serves as Lead Senior Staff Writer for JAMA Medical News. They delve into exciting topics like a groundbreaking blood test for Alzheimer’s, the repurposing of GLP-1 receptor agonists, and potential risks from inhaling wildfire smoke. They also discuss the importance of blood-based biomarkers and advancements in Alzheimer’s diagnosis and treatment, emphasizing the need for responsible implementation in clinical settings.