Richard Van Norden, Nature's Features Editor, joins to discuss the highlights of 2024's scientific advancements. They chat about the impact of Ozempic in tackling obesity and diabetes, alongside entertaining yearly quizzes on major scientific breakthroughs. Insights on CAR T-cell therapies offer a glimpse into innovative cancer treatments. Highlighting Nature's 10, they celebrate key figures in science, including a savvy economist stepping into politics. Packed with humor and informative content, this conversation is both captivating and thought-provoking!