Richard Miller

In this enlightening discussion, aging experts Steven Austad, Richard Miller, and Matt Kaeberlein delve into the science of aging. They explore the connection between healthspan and lifespan, emphasizing effective interventions like rapamycin and senolytics. The panel critiques the funding challenges in aging research and advocates for more focus on geroscience. Additionally, they examine the complexities of biological age measurements and the potential of GLP-1 receptor agonists in promoting longevity. Packed with humor, insights, and scientific rigor, this conversation is a must-listen!

Richard Miller, a pathology professor at the University of Michigan and architect of the Interventions Testing Program, dives into the intriguing world of longevity research. He discusses groundbreaking findings on drugs like rapamycin and metformin, shedding light on their effects on lifespan in mice. Miller also explores the myths surrounding aging, the value of negative results from studies, and the nuances of using compounds like acarbose and nicotinamide riboside. His insights challenge conventional views and highlight the complexities of drug testing in the quest for a longer life.

This episode, a tale of a wonder drug that will make you wonder about way more than just drugs.   Doctor-reporter Avir Mitra follows the epic and fantastical journey of a molecule dug out of a distant patch of dirt that would go on to make billions of dollars, prolong millions of lives, and teach us something fundamental we didn’t know about ourselves. Along the way, he meets a geriatric mouse named Ike, an immigrant dad who’s a little bit cool sometimes, a prophetic dream that prompts a thousand-mile journey, an ice cream container that may or may not be an accessory to international drug smuggling, and - most important of all - an obscure protein that’s calling the shots in every one of your cells RIGHT NOW. This episode was reported by Avir Mitra and was produced by Sarah Qari, Pat Walters, Suzie Lechtenberg, with help from Carin Leong and Rachael Cusick. Special thanks to Richard Miller, Stuart Schreiber, Joanne Van Tilburg, and Bethany Halford. Support Radiolab by becoming a member today at Radiolab.org/donate.  **This episode was taped prior to the news that David Sabatini was fired from The Howard Hughes Medical Institute and prior to his resignation from the Whitehead Institute. More information about Sabatini’s alleged misconduct and the investigation into his behavior can be found here.