Ralph DeFronzo

Renowned diabetes researcher and clinician with five decades of work on insulin resistance; instrumental in bringing metformin to the U.S. and in development of SGLT2 inhibitors.

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Feb 24, 2025 • 2h 27min

#337 - Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.

Ralph DeFronzo, a distinguished diabetes researcher, discusses his groundbreaking insights on insulin resistance and its effects on metabolic health. He delves into the impacts on organs like the liver and muscles, the revolutionary euglycemic clamp technique, and the emerging role of drugs such as SGLT2 inhibitors and GLP-1 receptor agonists. The conversation also touches on the alarming rise of type 2 diabetes in adolescents, addressing lifestyle and genetic factors. DeFronzo’s deep knowledge offers a masterclass on diagnosis, treatment, and the future of diabetes care.

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