Prof. Santiago Schnell

Venezuelan-born mathematical biologist and academic leader known for work in quantitative biology and enzyme kinetics, including the Schnell–Mendoza equation; William K. Warren Foundation Dean of the College of Science at the University of Notre Dame and professor of Biological Sciences and Applied & Computational Mathematics & Statistics.

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Oct 15, 2025 • 50min

The Measure of All Things? Rethinking Constants and Replicability in the Life Sciences – Prof. Santiago Schnell

Prof. Santiago Schnell, a prominent mathematical biologist and dean at Notre Dame, discusses critical issues in life sciences measurement and replicability. He emphasizes how precise measurements enhance scientific modeling, drawing on historical examples from Copernicus to Newton. Schnell reveals alarming variability in enzyme kinetics reporting and the importance of replicability as science's gold standard. He advocates for curating better datasets and launching interlaboratory studies to improve measurement practices and collaboration between philosophy and quantitative biology.

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