Peter Grinspoon, a physician and cannabis specialist, and Kevin Sabet, a drug policy advisor, engage in a lively debate about the consequences of legalized cannabis. They discuss the significant increase in public support for marijuana, alongside health risks such as heart attacks and psychosis, particularly among young users. The conversation addresses the complexities of commercialization, regulation, and the historical context of cannabis use, raising questions about personal freedom versus public health and the future of cannabis legislation in the U.S.