Paul Zarkowski

In this discussion, Dr. Paul Zarkowski, a psychiatrist and faculty contributor, dives into his comparative study on lithium versus quetiapine for treatment-resistant depression. He reveals real-world data on efficacy and side effects that spans an entire year. The conversation explores short-term remission rates and how these treatments fare against STAR*D findings. Zarkowski highlights the implications of side effects and the importance of individualized treatment choices, providing valuable insights for clinicians navigating difficult cases.

Dr. Paul Zarkowski, a psychiatrist and researcher known for his analysis of the STAR*D trial data, dives into the controversial belief surrounding SSRI side effects. He discusses whether these effects truly diminish over time, revealing that some patients may actually face worsening symptoms. Zarkowski explains concepts like survivor bias and presents data showing distinct side-effect trajectories. He also highlights persistent problems such as sexual and sleep-related side effects and stresses the importance of early assessments for effective patient counseling.