Robert Rosner, a notable physicist from the University of Chicago, and Paul Wilson, a leading nuclear engineering professor at the University of Wisconsin-Madison, dive deep into the intricate history of nuclear fission. They discuss the groundbreaking work at Chicago Pile 1 and its pivotal role in the Manhattan Project. The conversation touches on the complexities of managing nuclear reactions, the moral dilemmas faced by scientists during the era, and interesting parallels between nuclear dynamics and pandemic management. Their insights illuminate the profound impact of nuclear research on both science and society.