Paul Morris is a senior clinical lecturer and interventional cardiologist, while Hazel Haley is a consultant interventional cardiologist, both hailing from Sheffield. They delve into the innovative world of virtual fractional flow reserve (VFFR) and its clinical implications. Insights from their VIRTU-4 study reveal how VFFR impacts patient management in coronary syndromes, shifting strategies towards enhanced therapies and PCI. They also discuss the limitations of VFFR and the importance of ongoing research in advancing non-invasive assessment tools in cardiology.