Dr. Pat Kopko, a transfusion medicine physician at UC San Diego and an early adopter of pathogen-reduced platelets, shares insightful lessons from her hospital's 2017 implementation. She discusses the impetus behind adopting this technology, including previous septic transfusion experiences, and the importance of safety culture. Pat explains challenges faced with blood suppliers, operational readiness, and the phased strategy for prioritizing patients. Ethical considerations in patient care and practical choices around supply and matching are highlighted, paving the way for future advancements in transfusion safety.