Nigel Denning, a pioneer in therapeutic psychedelics, discusses the transformative potential of MDMA and psilocybin in treating mental health issues. He raises concerns about the proper implementation and training in psychedelic-assisted therapy, emphasizing the need for structured treatment and integration. The conversation highlights Australia's recent legalization journey, the importance of community support, and collaboration in therapy. Denning also addresses skepticism about the science behind psychedelics and advocates for a personalized approach in therapeutic practices.