In this enlightening discussion, Natalie McDermott, a paediatric infectious diseases consultant, shares her harrowing journey with severe COVID and its aftermath, linking it to autoimmune and neurological conditions. Claire Bryant, a Professor at the University of Cambridge, delves into how COVID could lead to lasting changes in our immune responses. They explore the concept of “immunity debt,” the unusual patterns of infections post-lockdown, and whether COVID itself is responsible for emerging immune deficits. The conversation reveals the intricate connections between COVID and our immune health.