Molly Gibson

Co-founder and CEO of Expedition Medicines, a Flagship Pioneering–backed company developing generative covalent small-molecule chemistry and partnering with pharma to drug difficult targets.

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Oct 22, 2025 • 10min

Flagship Pioneering announced its newest company to emerge out of stealth mode today: Expedition Medicines. It is leveraging generative design for small molecule covalent chemistry

Molly Gibson, Co-founder and CEO of Expedition Medicines, dives into the innovative world of generative covalent small-molecule chemistry. She explains how her company is revolutionizing drug development with a $50 million backing and a partnership with Pfizer to tackle challenging targets like prostate cancer. Listeners will learn about the technology behind covalent chemistry, real-world applications, and the use of AI to generate new drug candidates. Molly also highlights Expedition's unique approach compared to other biotech firms, emphasizing their focus on previously undrugged targets.

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