Molly Brett, a primary care physician and associate editor for NEJM Journal Watch, joins the hosts to discuss groundbreaking findings in medical practice. They dive into the cognitive safety of very low LDL levels, raising intriguing questions. The podcast also explores suzetrogine as a promising non-opioid option for acute pain. Additionally, they evaluate the safety of SGLT2 inhibitors, linking them to peripheral artery disease. Finally, a debate unfolds over restrictive versus liberal transfusion strategies in acute myocardial infarction, shedding light on their long-term implications.