In this discussion, astrobiologist Michael Wong, who studies life detection on exoplanets, joins biologist Mohamed Noor, a science advisor for Star Trek Discovery. They delve into how Star Trek shapes the scientific exploration of extraterrestrial life. Jaime Green, a science journalist and author, adds to the conversation by exploring the influence of science fiction on actual astrobiological inquiry. They tackle topics like directed panspermia, the concept of alien evolution, and the ethical challenges posed by potential first contact with radically different life forms.