Milton Packer, a pioneer in heart failure research with over 500 publications, joins the discussion on the groundbreaking SUMMIT trial. The trial investigated tirzepatide's impact on obese heart failure patients, revealing reduced risks of cardiovascular death and enhanced quality of life. The conversation covers key insights from recent trials, the effectiveness of managing heart failure alongside obesity, and the collaboration between academia and industry in medical research. Packer sheds light on the trial's strengths, limitations, and the need for further exploration in weight management.