Milton Hershey, confectioner and founder of the Lancaster Caramel Company, overcomes failures to become a millionaire. He becomes interested in chocolate and starts his own candy-making business, the Lancaster Caramel Company. Facing financial difficulties, he works tirelessly to sell enough caramels and successfully delivers a large order to achieve success for the first time in his career.

Marie Curie and Milton Hershey go head-to-head in a trivia game. They discuss Curie's challenges as a female scientist and Hershey's success as a chocolate maker. The hosts also reveal Curie's middle name and joke about gross chocolates.