Michele Redell, a physician at Texas Children’s Cancer Center, and Mark Litzow from Mayo Clinic, dive into the complexities of pediatric leukemias. They discuss the Pediatric Acute Leukemia Screening Trial and the unique challenges in treating acute myeloid leukemia. The conversations explore crucial studies on drug responses in children versus adults, and advancements in CAR-T therapy. Insights into managing relapsed acute lymphoblastic leukemia showcase new strategies aimed at improving outcomes for young patients facing these formidable challenges.