In this intriguing discussion, Professor Michele Brignole, a distinguished expert on syncope from Italy, shares his insights on the evaluation and management of this puzzling condition. He highlights a standardized three-stage diagnostic approach and the importance of differentiating cardiac causes. The conversation dives into diagnostic strategies for unexplained syncope, emphasizing advanced monitoring techniques, especially for elderly patients. Listeners will learn about the significance of blood pressure variations and innovative methods like ambulatory monitoring.