In this discussion, Jim Miller, a PharmD specializing in critical care, dives into the DESIRE trial, revealing dexmedetomidine's pharmacokinetic advantages and its role in sedation for sepsis patients. He tackles the complexities of changing primary outcomes mid-study and shares insights from his novel research. Meanwhile, Michael Liu, a PharmD with dual board certifications, recounts a gripping in-flight medical emergency he handled, highlighting the unique challenges faced outside a hospital and offering invaluable advice for healthcare professionals in crisis situations.