Dr. Michael Klompas, a leading expert in sepsis, joins to unpack the complexities surrounding this often-misunderstood condition. They discuss the varying presentations of sepsis and the critical risks of misdiagnosis in atypical cases. A retrospective analysis reveals how infection sites and organ dysfunction impact patient outcomes. Klompas emphasizes the importance of precise classifications and the necessity for clinical judgment over rigid prediction models. The conversation sheds light on treating sepsis as a spectrum, calling for tailored management strategies.