In this conversation, Mike Israetel, a sports scientist and hypertrophy expert, Eric Helms, a leading coach and researcher, and Menno Henselmans, a data-driven bodybuilding coach, discuss controversial fitness beliefs. They debate the significance of soreness as an indicator of growth and the nuances of periodization for muscle development. The trio challenges common misconceptions about hypertrophy, emphasizing volume over external load and the role of training intensity. They also explore training to failure and share strategies for effective adaptation to high-volume training.