Mehdi Mollapour, a Professor of Urology, Biochemistry, and Molecular Biology at Upstate Medical University, leads a discussion with colleagues Jennifer Heritz and Sarah Backe on the vital role of molecular chaperones in tumor suppressor stability. They delve into how chaperones like Hsp70 and Hsp90 are crucial in supporting the functionality of these proteins, preventing tumorigenesis. The conversation reveals the significant impact of co-chaperones and discusses the critical gaps in research surrounding these interactions in cancer pathways.