Matthew Disney

Dr. Matthew Disney, an expert in small-molecule therapeutics at the UF Scripps Institute, dives into the revolutionary potential of RNA as a therapeutic target. He explores its pathogenic roles in diseases like ALS and myotonic dystrophy, and discusses innovative strategies to design small molecules that target structured RNA. Disney also highlights how RIBOTACs can recruit RNA-degrading enzymes, and shares insights on targeting viral genomes, including strategies for inhibiting SARS-CoV-2, showcasing the promising future of RNA therapeutics in combating various diseases.

Matthew Disney, a Professor and Chair at the University of Florida Scripps Institute, talks about pioneering the field of drugging RNAs with small molecules. Topics include eureka moments, challenges, RIBOTACs, and future opportunities.