Dr. Amy Gelfand, an expert on the glymphatic system, joins Dr. Matthew Bender, a specialist in intracranial hypertension, to explore the links between glymphatic outflow and transverse sinus stenosis. They discuss how glymphatic dysfunction may worsen idiopathic intracranial hypertension, the role of diffusion tensor imaging in brain fluid dynamics, and the implications of obesity in this condition. The conversation also touches on treatment strategies, including GLP-1 receptor agonists and venous sinus stenting.