Mark Ruffalo, an Oscar-nominated actor famous for his roles in Spotlight and as the Incredible Hulk, discusses his diverse career and recent role in the dark comedy Poor Things. He shares insights into transitioning to comedic acting and the complexities of his character. Ruffalo opens up about his battle with a brain tumor and how it reshaped his life, reflecting on emotional vulnerability. He also delves into maintaining anonymity in bustling New York City, sharing humorous tips for blending in.

Mark Ruffalo, acclaimed actor and activist known for his roles in films like Spotlight and The Avengers, shares captivating insights from his personal journey. He humorously reflects on his humble beginnings in Wisconsin and the challenges of moving to Hollywood. The conversation takes a serious turn as he opens up about his health scare with a brain tumor, blending humor with vulnerability. Ruffalo also discusses the powerful intersection of creativity and activism, emphasizing storytelling's role in social change, and fondly recalls the impact of LGBTQ+ representation in media.

Mark Ruffalo discusses his dual identity, fear of SNL, health scare, and recent testimony to Congress. The episode also delves into his family history, struggles with dyslexia, and dreams for creative inspiration.

Emma Stone, Willem Dafoe, Mark Ruffalo, and Ramy Youssef discuss their experiences working on 'Poor Things', including set design challenges and unexpected offers. They also explore the complexities of their characters, navigating British accents, and dancing through absurdity in comedic scenes.

Explore reflections on childhood experiences and the impact of films, collaboration with actors, financial management tips, emotional highs and lows of the Oscars, challenges of dialects and character creation, struggles and uniqueness of dyslexia in memorizing scripts, Canadian comedy talent, visual aesthetics in film creation, themes of love and betrayal, music evolution, and home-based music creation.