In this engaging discussion, Dr. Mark Peters, a leading expert in Pediatric Intensive Care from University College London, sheds light on the groundbreaking Oxy-PICU trial. He delves into the evolution of oxygenation strategies for critically ill children, highlighting a shift towards conservative targets that can reduce mortality and costs. The conversation emphasizes the significance of pragmatic trial design and the real-world implications of research findings, aiming to transform clinical practices in pediatric critical care.