In this engaging discussion, Prof. Mark Humphries, Chair in Computational Neuroscience at the University of Nottingham, unpacks the fascinating world of neural spikes. He explores how neurons communicate, the surprising concept of 'dark neurons,' and why many spikes fail to reach their destination. The conversation touches on the balance of excitatory and inhibitory inputs in the brain, the evolution of neuroscience technology, and how our brain processes visual information. Humphries also emphasizes the importance of accessible science communication.