Marion Koopmans, a renowned virologist instrumental in the development of the COVID-19 PCR test, discusses the urgent need for a sustainable flu surveillance network in Europe to learn from U.S. models. Matthew Cobb, an author and scientist, reflects on the Asilomar conference's legacy in shaping genetic engineering guidelines, while Shobita Parthasarathy raises ethical concerns about equity in scientific self-regulation. The conversation highlights the importance of public trust and inclusive dialogue as science grapples with emerging viral threats.