In this discussion, Lynn Warner-Stevenson, Director of Cardiomyopathy at Vanderbilt University, dives into intriguing sex differences in heart failure. She emphasizes the varying treatment responses between men and women, stressing the importance of tailored approaches. Carlos Aguilar summarizes recent cardiovascular research, highlighting breakthroughs in understanding coronary spasms and their implications. The conversation also touches on historical studies, like the London Bus Driver Trial, showcasing the impact of physical activity on heart health.