Roland Griffiths, a pioneering psychedelic researcher, discusses how psilocybin can ease the fear of death, especially in terminal patients. Lou Lukas, a palliative medicine physician, shares insights on integrating psychedelic therapy into end-of-life care. Anthony Bossis, a clinical psychologist, highlights the transformative, mystical experiences that psychedelics evoke, reshaping perceptions of mortality. Together, they explore how psychedelics can foster acceptance, alleviate existential anxiety, and encourage meaningful discussions about life and legacy.