Larry David, the comedic genius behind Seinfeld and Curb Your Enthusiasm, joins Conan for a laugh-filled conversation. He shares his mixed feelings about friendship with Conan and discusses the quirks of hosting parties, introducing the idea of a 'party sheriff.' Liza Powel O’Brien, Conan’s wife, pops in to share insights about her podcast, Significant Others, while they also reminisce about Larry's unforgettable stint on Saturday Night Live. Expect sharp humor and candid reflections on comedy and relationships!