In this discussion, Dr. Justin Morgenstern, an emergency physician and creator of First10EM.com, joins Lauren Fowler, a neuroscience professor focusing on fatigue, and Dr. Emily Hirsh, an associate professor dedicated to faculty wellbeing. They dive into the critical issue of fatigue in emergency medicine, revealing its ties to shift work and how it impairs performance and patient care. Insights into managing burnout, recent research findings on fatigue assessment, and the importance of systemic changes highlight the necessity for a healthier work environment in this demanding field.