Dr. Laura Walker, an Associate Professor of Emergency Medicine at the Mayo Clinic, dives into the transformative role of AI in assessing medical literature. She reveals how large language models like ChatGPT are reshaping critical appraisal in evidence-based medicine. The conversation explores AI's strengths and limitations, emphasizing the synergy between human judgment and machine intelligence. Additionally, she addresses the implications for diagnostic processes, shedding light on the financial costs and ethical considerations of AI integration in healthcare.