Experts Laura Piddock and Margaret McCartney discuss the ongoing challenges of antibiotic resistance. Marine biologist Helen Scales predicts future ocean changes. Cosmologist Andrew Pontzen talks about black holes. Food scientist Stuart Farrimond explains the EU ban on smoky flavored crisps.

Melvyn Bragg and guests discuss penicillin, discovered by Alexander Fleming in 1928. It is said he noticed some blue-green penicillium mould on an uncovered petri dish at his hospital laboratory, and that this mould had inhibited bacterial growth around it. After further work, Fleming filtered a broth of the mould and called that penicillin, hoping it would be useful as a disinfectant. Howard Florey and Ernst Chain later shared a Nobel Prize in Medicine with Fleming, for their role in developing a way of mass-producing the life-saving drug. Evolutionary theory predicted the risk of resistance from the start and, almost from the beginning of this 'golden age' of antibacterials, scientists have been looking for ways to extend the lifespan of antibiotics.WithLaura Piddock Professor of Microbiology at the University of BirminghamChristoph Tang Professor of Cellular Pathology and Professorial Fellow at Exeter College at the University of OxfordAndSteve Jones Emeritus Professor of Genetics at University College, LondonProducer: Simon Tillotson.