Dr. Lane Smith, a critical care medicine specialist at Atrium Health Carolinas Medical Center, dives deep into refractory distributive shock treatment. He discusses the innovative use of angiotensin II, shedding light on its methodology and outcomes. The conversation navigates the challenges of managing critical care in ICU settings, particularly focusing on organ dysfunction and treatment customization. Smith emphasizes the evolution of vasopressors, advocating for critical thinking in clinical practice as new alternatives emerge.