Dr. Kristin Cadenhead, an expert in recognizing and treating psychosis in autism, discusses the challenges of differentiating between autism and psychosis. She explores the importance of changes in behavior, clinical symptoms, and family psychiatric history. The chapter also covers different approaches for treating psychosis in autism, including medication options and collaboration with neurologists. Additionally, the cautious approach to using stimulants in individuals with psychosis is discussed, as well as the stigma associated with psychotic disorders and the challenges in treating individuals with both psychosis and autism.