Three immunologist sisters, Drs. Mindy, Amy, and Kristen Engevik, discuss microbial-host crosstalk, gastrointestinal disorders, and purinergic signaling. They share insights on immune dysregulation in severe COVID-19, advancements in immunotherapy, and their personal journeys in gut immunology research. The episode also touches on empowering women in STEM, challenges faced, and a fun discussion on superpowers.