In this engaging discussion, Dr. Kevin Duff, a board-certified clinical neuropsychologist and Alzheimer’s researcher, and Dr. Clifford Jack, a leading expert in Alzheimer’s biology from Mayo Clinic, explore the latest updates in diagnosing and staging Alzheimer’s disease. They delve into the complexities of combining biological markers with cognitive assessments, the predictive validity of amyloid PET scans in asymptomatic individuals, and the evolving criteria for effective patient care. Their insights may reshape how we understand and approach Alzheimer's diagnostics, offering hope for future advancements.