Exploring challenging cases of Parkinson-Plus syndromes like Progressive Supranuclear Palsy and Corticobasal Syndrome, with emphasis on accurate diagnosis and management strategies. Discussing dysautonomia, multiple system atrophy, and differentiating MSA Parkinsonism from MSA Cerebellar types. Highlighting patient management for dysautonomia, orthostatic hypotension, and dementia with Lewy bodies in a comprehensive approach to neurology care.